ABSTRACT
Polycystic ovary syndrome [PCOS] is the most common cause of hyperandrogenism, and anovulatory infertility; its affects 5-10% of females at their reproductive age. Prostate specific antigen is a glycoprotein that is secreted from the prostate in males and from paraurethral glands and breast in female. To evaluate the total and free prostate specific antigen levels in female with PCOS, and find out its relation with FSH, LH, Prolactin and testosterone [F,T]. Eight patients with PCOS diagnosed based on three criteria. High LH: FSH ratio; LH luteinizing hormone to FSH follicle stimulating hormone is 2:1 or more particularly in the early phase of menstrual cycle [3-6] day. Ultrasound reveals polycystic ovaries. Biomedical hyperandrogenism. Elevated androgens particularly free testosterone. Forty normal fertile females servced as a control group in this study. Blood samples were taken from all individuals from 3-6 days of menstrual cycle to measure total and free prostate specific antigen, total and free testosterone [by enzyme linked immunosorbent assay] and FSH, LH, Prolactin [by Immunoadiometric assay]. Patients with PCOS and controls differed significantly in all parameters studied, except FSH [P] > 0.05]. LH and LH: FSH ration were significantly elevated in PCOS group compared to normal control group [11.9 +/- 5.4 vs. 7.0 +/- 0.6] an d[2.3 +/- 1.1 vs. 1.2 +/- 0.01] respectively. Total and free testosterone were significantly elevated in patient with PCOS compared to non control group [50 +/- 9.6 vs. 24 +/- 3.4] and [8.9 +/- 1.0 vs. 1.9 +/- 0.4] respectively. Total and free PSA significantly elevated in patient with PCOS compared to normal control group [1.2 +/- 0.4 vs. 0.1 +/- 0.02] and [0.04 +/- 0.01 vs. 0.01 +/- 0.003] respectively. Positive correlation between T-PSA, F-PSA and T-testo, F-testo. Total and free serum prostate specific antigen levels are higher in patient with PCOS. Serum PSA measurement might be marker of hyperandrogenism in females suffering from PCOS